{"id":31125,"date":"2010-01-18T05:00:00","date_gmt":"2010-01-18T10:00:00","guid":{"rendered":"https:\/\/www.yorku.ca\/researchdev\/2010\/01\/18\/regular-exercise-can-turn-back-the-clock-for-aging-muscle-2\/"},"modified":"2025-01-29T14:36:50","modified_gmt":"2025-01-29T19:36:50","slug":"regular-exercise-can-turn-back-the-clock-for-aging-muscle-2","status":"publish","type":"post","link":"https:\/\/www.yorku.ca\/research\/2010\/01\/18\/regular-exercise-can-turn-back-the-clock-for-aging-muscle-2\/","title":{"rendered":"Regular exercise can turn back the clock for aging muscle"},"content":{"rendered":"

<\/p>\n

It may not be the fountain of youth, but researchers at 快播视频 have discovered that regular exercise can effectively turn back the clock for aging skeletal muscle.<\/p>\n

The study,\u00a0\u201cMolecular basis for an attenuated mitochondrial adaptive plasticity in aged skeletal muscle,\u201d was recently published in the journal Aging<\/a><\/em>. The results indicate that the elderly are able to rebuild muscle mass,\u00a0and while they will not achieve the abs of a 20-year-old, they can reverse significant damage and loss of muscle function caused by inactivity and old age.<\/p>\n

The research team led by Professor David Hood, Canada Research Chair in\u00a0Cell Physiology and a professor in the School of Kinesiology & Health Sciences in York\u2019s Faculty of Health, carried out the study as part of an ongoing series of investigations into the benefits of exercise (see YFile<\/em>,\u00a0May 11, 2007<\/a> & March 2, 2009<\/a>). This most recent study demonstrates that even in the elderly (individuals of 70 or 80 human years of age), regular exercise has the effect of rejuvenating muscle health, and these benefits are demonstrated by \"\"reduced fatigue and enhanced cellular function.\u00a0The study\u00a0adds weight to a growing body of findings by Hood and his research team that exercise plays a key role in achieving long-term health, even into advanced age.<\/p>\n

Right: David Hood<\/strong><\/p><\/blockquote>\n

\u201cWe found that muscle does adapt, but it takes a longer time for that adaptation to take place,\u201d says Hood. \u201cIt is not a question anymore that regular exercise offers little benefit for elderly individuals because their muscles won\u2019t adapt. That is not the case. The muscles of older individuals do adapt, they just don\u2019t adapt as robustly or as quickly as younger individuals.\u201d<\/p>\n

Hood says the study showed that elderly muscle will continue to improve in its responsiveness as long as the exercise continues. \"It may take more time but the benefits are definitely there,\" he says.<\/p>\n

\"To prove this, we used a well-established animal model of aging, the Fisher Brown Norway\u00a0rat at young and very old ages. To avoid any differences in exercise behaviour between ages, we used a chronic stimulation model of muscle contraction in which the muscles of one leg were made to contract for three hours a day for seven consecutive days. This represents a standardized high exercise workload which can be imposed on one leg of both the young and old animals while the opposite leg remains at rest,\" explains Hood.<\/p>\n\n\n\n
In cell biology, mitochondria<\/strong> are membrane\u00a0enclosed organelles found in most\u00a0cells of complex organisms. Mitochondria are sometimes described as the powerplants of cells because of their role in generating most of the cell's chemical energy. Mitochondria are involved in a variety of other processes,\u00a0such as signaling, cellular differentiation into tissues, cell death, as well as the control of the cell cycle and cell growth.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

At the end of the seven-day period, the adaptability of the muscle with respect to its ability to withstand fatigue was assessed. Specifically, Hood's research team looked at\u00a0key components of muscle cell health, including\u00a0the production of mitochondria and proteins which are known regulators of mitochondrial synthesis. \"While the older muscle fatigued more rapidly than the young muscle, this fatigue was reduced by the exercise and the muscle was 'rescued', allowing it to perform similarly to that of the young muscle,\" says Hood. In the younger muscle, regular exercise increased the mitochondrial content to a greater degree than in the old muscle, but old muscle did experience an increase and there was reduced apoptosis (cell death) in the old muscle.<\/p>\n

Hood says the findings mean that exercise carries huge benefits for all ages, and muscle, no matter what its age, can adapt regardless of how old a person is. \u201cPeople should be encouraged to exercise continually throughout their life,\u201d says Hood. \u201cDon't expect that as you get older, the adaptations will happen as quickly, but an ongoing lifestyle choice to exercise is very important.\u201d<\/p>\n

The benefits, says Hood, are many for the elderly include and include stronger muscles, greater resistance to injury and\u00a0bone breakage, and enhanced metabolism. \u201cRegular exercise means being less tired doing normal daily activities, improved metabolism which helps you break down fat making you more sensitive to insulin, which is important in preventing pre-diabetic conditions. Better metabolism improves whole body function and wellness.\u201d<\/p>\n

Muscle Health Research Centre<\/strong><\/p>\n

Hood's lab is part of York's new Muscle Health Research Centre<\/a> (MHRC),\u00a0which is the first of its kind in Canada. The centre will celebrate its official opening on Wednesday, Jan. 20, at 10:30am.<\/span><\/p>\n

\u201cThis centre is unique in that we\u2019re zeroing in on skeletal muscle and its relationship to health, with a strong focus on what exercise can do,\u201d says Hood,\u00a0who will serve as the centre's\u00a0director.\u00a0\u201cWe\u2019re looking for new discoveries on how exercise can benefit Canadians through adaptations in the metabolism and structure of muscle.\u201d<\/p>\n

The MHRC conducts collaborative research with scientists from the School of Kinesiology & Health Science and the Department of Biology.<\/p>\n

\u201cLike all research centres at York, the MHRC has an interdisciplinary mandate \u2013 that is, enabling researchers from different departments and disciplines to work together towards a common goal,\u201d says Hood.<\/p>\n

Scientists from the MHRC are investigating topics such as muscle metabolism, muscle development and muscle adaptations to exercise, metabolic disease and cancer. Professor Tara Haas and colleagues in the MHRC recently identified a cell-signalling process that stimulates blood vessel growth and may help individuals with diabetes to exercise and thereby improve their health (see YFile<\/em>, Nov. 17, 2009<\/a>).<\/p>\n

\u201cAs a leading research institution, we\u2019re concerned with bringing the work of our scientists to bear on the real world and improving the health and well-being of Canadians,\u201d says Harvey Skinner, dean of\u00a0York's Faculty of Health. The centre will serve as an innovative hub for the life sciences within York\u2019s Faculty of Health, generating new knowledge and disseminating research findings to the public and the health system.<\/p>\n

The opening ceremony will feature guest speakers, including Olympic figure skater Barbara Underhill; Philip Gardiner, director of the Health, Leisure & Human Performance Research Institute at the\u00a0University of Manitoba; and Jane Aubin, scientific director of the Canadian Institutes of Health Reserach<\/a> Institute of Musculoskeletal Health and Arthritis<\/a>.<\/p>\n

The opening will take place Jan. 20, from 10:30am to 1pm, in the\u00a0Execultive Learning Centre\u00a0located in\u00a0X106 Seymour Schulich Building\u00a0on York's Keele campus. For more information, contact Kathy Thomas at thomask@yorku.ca<\/a>. To learn more about muscle health research at 快播视频, visit the MHRC<\/a> Web site or contact Hood at dhood@yorku.ca<\/a>.<\/p>\n

By Jenny Pitt-Clark, YFile editor<\/em><\/p>\n

Republished courtesy of YFile<\/a> \u2013 快播视频\u2019s daily e-bulletin.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

It may not be the fountain of youth, but researchers at 快播视频 have discovered that regular exercise can effectively turn back the clock for aging skeletal muscle. The study,\u00a0\u201cMolecular basis for an attenuated mitochondrial adaptive plasticity in aged skeletal muscle,\u201d was recently published in the journal Aging. The results indicate that the elderly are […]<\/p>\n","protected":false},"author":37,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","footnotes":""},"categories":[197,6188,58,381,6189,39,102],"tags":[375,376,124,35,219,36,377,337,378,379,38,380,321,278,40,280],"class_list":["post-31125","post","type-post","status-publish","format-standard","hentry","category-awards-honours","category-canada-research-chair-awards-honours","category-health-research","category-innovation-in-the-world","category-muscle-health-research-centre-research-centres","category-news","category-research-centres","tag-aging","tag-barbara-underhill","tag-canada-research-chair","tag-canadian-institutes-of-health-research","tag-cancer","tag-cihr","tag-david-hood","tag-department-of-biology","tag-elderly","tag-exercise","tag-faculty-of-health","tag-harvey-skinner","tag-human-body","tag-muscle-health-research-centre","tag-school-of-kinesiology-health-science","tag-tara-haas"],"acf":[],"yoast_head":"\nRegular exercise can turn back the clock for aging muscle | Research & Innovation<\/title>\n<meta name=\"description\" content=\"For immediate release: Regular exercise can turn back the clock for aging muscle. 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